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How do I know if Imiquimod is working? The skin may weep, peel, crack or even blister and then scab over. The area may be itchy or sore, painful and burn. This is caused by the abnormal cells dying and a sign that the treatment is working. The skin reaction tends to be worst in week 2 to 3 of application. How long does it take for Aldara to start working? Aldara should not be used for more than 16 weeks at a time. It usually takes 8-10 weeks for your warts to disappear but warts may clear as early as 4 weeks. If your warts reappear, talk to your doctor. If your skin reacts badly to Aldara, your doctor may recommend that you stop treatment for a few days. How often should Aldara be applied? 5 times per week
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